Thousands of people take part in the London to Brighton bike ride from Clapham Common.
The British Heart Foundation, which organizes the fundraising race, said around 14,000 runners were expected to tackle the 54-mile course.
The first cyclists were due to leave at 6am, the last leaving around 9.30am, and they will all head to Brighton seafront where the ride will end.
The charity said: “This year will be the 45th anniversary of BHF London to Brighton Bike Ride. The charity hopes 2022 will raise over £2.8million.
“Among the runners will be Jason Cooper, drummer for British rock band The Cure.
“Jason will ride in memory of Paul ‘Ricky’ Welton, longtime Cure crew member and Jason’s drum tech, who tragically passed away shortly after suffering a heart attack on Cure’s last tour in 2019 .
“Jason will be joined by a team of riders for the event, cycling to raise funds in Ricky’s name and to help BHF’s vital research into heart and circulatory disease.”
The British Heart Foundation also said: “For the first time ever we are working with a number of other charities who will have runners in the event.
“The charities involved in the event will be present along the London-Brighton route and at the finish line.”
And the BHF added: “There are plenty of rest and refreshment points on the course.
“Ditchling Beacon is the last climb of this great event. Situated seven miles before the finish line, with an elevation of 248m, it is the highest point in East Sussex.
“Once you reach the top the view over Brighton is fantastic and well worth a stop as it’s the last refreshment point before the finish line.”
The weather promises to be wetter and cooler than some years, with sunshine more likely as the day progresses.